CALGARY, Canada, September 28 /PRNewswire/ --     Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ:ONCY) today 
announced that an oral presentation covering interim results from a U.K. 
Phase  Ia/Ib combination REOLYSIN(R) and radiation clinical trial for 
patients with advanced or metastatic cancers is scheduled to be presented 
at the National  Cancer Research Institute (NCRI) conference on October 2, 
2007 in Birmingham,  U.K. The presentation, entitled "Biological Approaches
to Radiosensitisation:  Viruses, Gene Therapy and Novel Radiosensitisers" 
will be presented by Dr.  Kevin Harrington of The Institute of Cancer 
Research, London and one of the  principal investigators for the trial. 
The conference runs from September 30  through October 3, 2007 in 
Birmingham, U.K.

"We are very pleased with the results of this trial to date," said Dr.
Brad Thompson, President and CEO of Oncolytics. "We continue to evaluate the
data and look forward to announcing final results."

To date, 22 patients have been treated with 15 having completed the
study. Five patients withdrew from the study, and two patients are still on
study.

A total of 11 patients in the Ia portion of the trial received two
intratumoural treatments of REOLYSIN(R) at dosages of 1x10(8), 1x10(9), or
1x10(10) TCID(50) with a constant localized radiation dose of 20 Gy given in
five fractions. Of these 11 patients, three patients (oesophageal, squamous
skin carcinoma and squamous cell scalp) experienced significant partial
responses.

One month following treatment, the oesophageal patient experienced a
28.5% reduction in the target tumour, with stable disease noted in four,
non-treated tumours. At two and three months, the target tumour had shrunk
64%, with stable disease continuing in the four non-treated tumours, 
including a 15% volume reduction in non-treated mediastinal disease that was 
maintained for more than six months. The squamous skin cancer patient 
experienced a 50% reduction in the target tumour, as well as stable disease 
in two, non-treated tumours at one, two and three months post treatment. 
The squamous cell scalp patient experienced stable disease in the target 
tumour for two months which then became a partial response at three months. 
This patient also experienced stable disease in one non-treated tumour 
measured at three months post-treatment.

Patients in the Ib portion received either two, four or six intratumoural
doses of REOLYSIN(R) at 1x10(10) TCID(50) with a constant localized radiation
dose of 36 Gy given in 12 fractions. Of the six patients who have completed
the study to date, three patients (colorectal, melanoma and lung cancer)
experienced tumour regression in the target tumour, as well as stable disease
in non-treated tumours.

The colorectal patient experienced a partial response with a more than
50% regression in the target tumour as well as stable disease in four,
non-treated tumours measured at one month following treatment. A melanoma
patient experienced minor regression in the target tumour as well as stable
disease in two, non-treated tumours at one and two months following 
treatment. A lung cancer patient experienced minor regression in the target 
tumour, as well as stable disease in three, non-treated tumours at two months 
following treatment.

The treatment has been well tolerated, with mostly Grade 1 or 2
toxicities noted including fatigue, lymphopenia, fever, and neutropenia. 
Grade 3 toxicities including cellulitis, dysphasia and diarrhoea were 
related to disease progression and not to the combination treatment. 
Viral replication was unaffected by cellular irradiation.

The primary objective of the Phase Ia/Ib trial is to determine the
maximum tolerated dose (MTD), dose limiting toxicity (DLT), and safety 
profile of REOLYSIN(R) when administered intratumourally to patients 
receiving radiation treatment. A secondary objective is to examine any 
evidence of anti-tumour activity. Eligible patients include those who have 
been diagnosed with advanced or metastatic solid tumours that are 
refractory (have not responded) to standard therapy or for which no 
curative standard therapy exists.

The principal investigators for the trial are Dr. Kevin Harrington of 
the Targeted Therapy Laboratory, The Institute of Cancer Research, Cancer 
Research UK Centre for Cell and Molecular Biology and Honorary Consultant 
in Clinical Oncology at The Royal Marsden NHS Foundation Trust, London, UK, 
and Dr. Alan Melcher of the Cancer Research U.K. Clinical Centre at 
St. James's University Hospital in Leeds. The trial is enrolling patients 
at the Royal Marsden and St. James's Hospitals in the U.K.

Further results of the combination REOLYSIN(R) and radiation trial are
scheduled to be presented at the AACR-NCI-EORTC International Conference on
Molecular Targets and Cancer Therapeutics in San Francisco October 22-26,
2007.

About Oncolytics Biotech Inc.

Oncolytics is a Calgary-based biotechnology company focused on the
development of oncolytic viruses as potential cancer therapeutics. 
Oncolytics' clinical program includes a variety of Phase I and Phase II human 
trials using REOLYSIN(R), its proprietary formulation of the human reovirus, 
alone and in combination with radiation or chemotherapy. For further 
information about Oncolytics, please visit http://www.oncolyticsbiotech.com

About The Institute of Cancer Research

The Institute of Cancer Research is Europe's leading cancer research
centre with expert scientists working on cutting edge research. It was 
founded in 1909 to carry out research into the causes of cancer and to 
develop new strategies for its prevention, diagnosis, treatment and care. 
Website at: http://www.icr.ac.uk

The Institute works in a unique partnership with The Royal Marsden NHS
Foundation Trust, forming the largest comprehensive cancer centre in Europe.
This relationship enables close daily contact between research scientists and
those on the frontline in the fight against cancer - the clinicians, the
carers and most importantly, the patients.

This press release contains forward-looking statements, within the
meaning of Section 21E of the Securities Exchange Act of 1934, as amended.
Forward-looking statements, including the Company's expectations related to
the Phase Ia/Ib U.K. combination REOLYSIN(R) and radiation clinical trial, 
and
the Company's belief as to the potential of REOLYSIN(R) as a cancer
therapeutic, involve known and unknown risks and uncertainties, which could
cause the Company's actual results to differ materially from those in the
forward-looking statements. Such risks and uncertainties include, among
others, the availability of funds and resources to pursue research and
development projects, the efficacy of REOLYSIN(R) as a cancer treatment, the
success and timely completion of clinical studies and trials, the Company's
ability to successfully commercialize REOLYSIN(R), uncertainties related to
the research and development of pharmaceuticals and uncertainties related to
the regulatory process. Investors should consult the Company's quarterly and
annual filings with the Canadian and U.S. securities commissions for
additional information on risks and uncertainties relating to the
forward-looking statements. Investors are cautioned against placing undue
reliance on forward-looking statements. The Company does not undertake to
update these forward-looking statements.